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. 2015 May 27;17(5):421–433. doi: 10.1016/j.neo.2015.04.003

Figure 4.

Figure 4

The absence of MMP9 leads to minimal changes in the cytokine environment in the C3(1)-Tag and MMTV-Neu mouse models of breast cancer. (A) Relative protein levels of a panel of cytokines in C3(1)-Tag;Mmp9+/+ versus C3(1)-Tag;Mmp9−/− and (B) MMTV-Neu;Mmp9+/+ versus MMTV-Neu;Mmp9−/− tumors. Each column represents a tumor from an individual mouse. The measured protein levels were normalized to an internal assay standard and plotted in a heat map. Statistical significance was determined by t tests using the Holm- Šídák method to correct for multiple comparisons, and the asterisk indicates P < .05. No differences were significant for B after correction for multiple comparisons. (C) The infiltration of macrophages and neutrophils/monocytes was not significantly influenced by Mmp9 gene expression in tumors from MMTV-Neu nor C3(1)-Tag mice. Infiltration was determined by immunohistochemistry of tumors from mice of the indicated genotypes.