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High IGFBP expression correlates with better prognosis of human breast cancer patients. The human breast cancer data set of expression profiles (GSE3494, n = 236) was analyzed for correlation of IGFBP expression with patient outcome. (A–F) Longer overall survival was observed in cancer patients with high expression of IGFBPs, except IGFBP-5 (D). Asterisks indicate statistical significance: *P < .05, **P < .01, or ***P < .001.
