Skip to main content
. 2015 Apr 28;6(6):635–640. doi: 10.1021/acsmedchemlett.5b00149

Figure 3.

Figure 3

Effects of compound 10 on ACh-mediated NO-dependent vasodilation. Mesenteric vascular arteries (MVA) isolated from SD rats were contracted to ∼80% of maximal vasoconstriction with 10 μM NA. (A) Dose–response curves for ACh-induced vasorelaxation (0.01–3 μM/30 s) were obtained in MVA under control conditions and after pretreatment with 1400W (1 μM) and subsequent treatment with l-NAME (100 μM). (B–F) Dose–response curves for ACh-mediated vasorelaxation were obtained in MVA under control conditions, and after pretreatment with increasing concentrations of compound 10 and subsequent treatment with l-NAME. Results are mean ± SEM of duplicates from four independent experiments for each condition. Asterisks refer to significant differences found between indicated curves assessed by two way ANOVA for repeated measures. *p < 0.05; **p < 0.01 vs l-NAME (panels A–C) or CTRL (panels D–F) curves, respectively.