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. 2015 Apr 20;6(6):683–688. doi: 10.1021/acsmedchemlett.5b00107

Table 1. Key Properties of Compound 1.

graphic file with name ml-2015-00107f_0005.jpg

IRAK4 IC50 (nM) 110
hPBMC IC50 (nM) 2300
LBE 0.44
no. of kinases tested 101
% of kinases >100× 89a
PSA (Å) 127
cLogD (pH 7.4) –1.7b
Papp (10–6 cm/s) 17c
a

Fold selectivity against in-house IRAK4 IC50.

b

From ACD Labs v10.

c

From MDCK cells.