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. 2015 Apr 24;6(6):671–676. doi: 10.1021/acsmedchemlett.5b00089

Table 2. SAR for Benzamide of 1,2,3-Triazolopiperidines.

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a

Human FLIPR pIC50 measured in a Ca2+ flux assay.

b

Rat FLIPR pIC50 measured in a Ca2+ flux assay; all data are the result of at least three assays run in triplicate with the mean value reported. The standard deviation is all cases was less than 2-fold.

c

HLM and RLM refer to human and rat liver microsomal preparations with data reported as the extraction ratio (ER).

d

CYP2C19 data was obtained from human liver microsomes. Details of all assay conditions are provided in the Supporting Information.