Table 2. In Vitro Activity of Compound 15 against Filamentous Fungi.
| MIC (μg/mL) |
|||
|---|---|---|---|
| Organism | ATCC # | Cmpd 20 | Am Ba |
| Aspergillus fumigatus | 20435 | 1 | 0.25 |
| Aspergillus fumigatus | MYA-32626 | 2 | 0.25 |
| Aspergillus flavus | 204304 | 1 | 0.25 |
| Aspergillus flavus | 22546 | 2 | 0.25 |
| Aspergillus flavus | 64025 | 1 | 0.5 |
| Aspergillus candidus | 13686 | 0.008 | 0.03 |
| Aspergillus clavatus | 10058 | 0.03 | 0.004 |
| Aspergillus niger | 16888 | 0.125 | 0.03 |
| Aspergillus niger | 64028 | 0.03 | 0.015 |
| Aspergillus ochraceus | 96919 | 0.25 | 0.25 |
| Emericella nidulans | 96921 | 0.125 | 1 |
| Fusarium oxysporum | 48112 | >64 | 1 |
| Rhizopus oryzae | 11886 | >64 | 0.03 |
| Sporothrix schenkii | 14284 | >64 | 0.5 |
| Trichophyton mentagrophytes | MYA-4439 | 0.5 | 0.06 |
| Trichophyton mentagrophytes | 28185 | 1 | 0.06 |
| Trichophyton rubrum | MYA-4438 | 2 | 0.03 |
a
Am B, amphothericin B.