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. 2015 Jun 16;5:11421. doi: 10.1038/srep11421

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Silymarin exhibits a statistically significant (P < 0.05) dose-dependent inhibition on the Rluc activity produced by BHK-CHIKV-NCT replicon. The Rluc activity was measured at 48 h post treatment. Vehicle–treated (0.1% DMSO) cells were used as control (“0”) concentration). Data from triplicate assays were plotted and analyzed from a non-parametric correlation (Spearman) two-tailed test (Graph Pad Prism Version 5, Graph Pad Software Inc., San Diego, CA).