Skip to main content
. 2015 Jul;43(7):944–950. doi: 10.1124/dmd.114.061705

TABLE 1.

Summary of DCF toxicokinetic parameters in plasma of FVB WT and FVB Mrp3-null after a single 75 mg/kg DCF dose

Data are expressed as mean ± S.E. of the mean for 10–12 subjects/group.

Group C0 t1/2 AUC0-tlast
µM min µM × min
WT 699 ± 31 74.1 ± 12.8 34,600 ± 2,100
KO 701 ± 38 108 ± 10 35,900 ± 2,500

C0, indicates the estimated DCF plasma concentration at time zero; t1/2, DCF elimination half-life; AUC0-tlast, area under the plasma concentration versus time curve for DCF from time zero to the last collected time point.