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Inhibition of OTS167 glucuronidation in UGTs (A), HLM (B), and HIM (B). HLM, HIM, UGT1A1, UGT1A3, UGT1A8, UGT1A9, and UGT1A10 were incubated with 3.4 µM, 1.7 µM, 5.7 µM, 2.2 µM, 3.7 µM, 3.4 µM, and 0.9 µM OTS167, respectively, in the presence of 2.5 µM nilotinib, 500 µM imipramine, 100 µM emodin, and 2.5 µM niflumic acid. Control incubations contained vehicle only. Data represent means ± S.D. of triple determinations in a single experiment.
