FIG 5.

Hypothesized composition of EBOV stocks with different particle/PFU ratios. The data presented in this work suggest that a high-particle/PFU-ratio stock is more potent in cynomolgus macaques than Vero E6 cell culture. We hypothesize that in this stock a larger proportion of the particles are infectious in only cynomolgus macaques, rather than infectious in both cynomolgus macaques and Vero E6 cells. Conversely, the low-particle/PFU-ratio stock may have a lower percentage of particles that are infectious in only cynomolgus macaques as a higher percentage are able to infect both Vero E6 cells and cynomolgus macaques.