FIG 8.

Hypothetical model to explain the effect of MRN on AAV replication during productive infection. (A) In the presence of HSV-1 the MRN complex is recruited within AAV replication compartments and favors both AAV genome replication and integration. AAV integrated genomes contribute to AAV replication, which is also directly performed using episomal AAV genomes as a template. (B) In the presence of AdV, the MRN complex is delocalized and then degraded. AAV integration is strongly reduced, resulting in a reduced level of AAV replication, and replicative forms arise solely from episomal genomes. The star indicates the presence of putative MRN binding sequences within the rep gene.