FIG 1.

Frequency of NK cell subsets in LNs from naive and SIV-infected macaques. (A) Representative gating for CD16 and CD56 subsets of CD45⁺ HLA-DR⁻ CD3⁻ NKG2a⁺ NK cells. (B) The frequency of NK cells among CD45⁺ lymphocytes is shown for lymphocytes isolated from the MLNs (black), PaLNs (blue), and PLNs (red). (C and D) Frequencies of three NK cell subsets among total CD45⁺ lymphocytes (C) and as a fraction of bulk NK cells (D) as defined by CD16 and CD56 expression from LN of naive (green), acutely infected (purple), and chronically infected (orange) animals. Horizontal bars indicate median values, and asterisks indicate significant differences by the Mann-Whitney U test (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001).