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Functional activity of LN NK cells from naive and SIV-infected macaques. Lymphocytes were isolated from the MLNs (black), PaLNs (blue), and PLNs (red) and were stimulated by treatment with PMA and ionomycin. IFN-γ (A), TNF-α (B), and MIP-1β (C) production and CD107a expression (D) by NK cells are shown. Horizontal bars indicate median values, and asterisks indicate significant differences by the Mann-Whitney U test (**, P < 0.01).
