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. 2015 Jun 16;5:10938. doi: 10.1038/srep10938

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(A) Structures of the compounds. Rosmarinic acid and EGCG are type-C inhibitors, which match two (CH and CHG) specific anchors and one (CH) specific anchor, respectively. In comparison, quercetin matches none of the specific anchors. (B) Results of compound profiling. The percentage of the remaining kinase activity is indicated from green (0%) to black (>50%). A compound is considered a potential inhibitor against kinases if the percentage of the remaining kinase activity is ≤50% at a compound concentration of 10 μM. (C) The target number of three compounds. Rosmarinic acid, EGCG, and quercetin inhibit 2 (3%), 9 (14%), and 39 (61%) of the 64 protein kinases, respectively. (D) IC₅₀ value of rosmarinic acid for wild-type EGFR. Docked poses of the compounds (E) rosmarinic acid, (F) EGCG, and (G) quercetin in EGFR. Hydrogen-bonding interactions are represented as green dashes.