TABLE 1.
Occurrence of ECM according to host-parasite strain context
| P. berghei strain | Presence of PbHMGB2 protein | Occurrence of ECMa |
|
|---|---|---|---|
| C57BL/6 mice | BALB/c mice | ||
| WT P. berghei ANKA | − | †, 100% ECM | No ECM, 100% death by hyperparasitemia |
| + | ND | †, 65% ECM | |
| KO P. berghei ANKA | − | 65% ECM survival | No ECM, 100% death by hyperparasitemia |
| + | †, 65% ECM | ||
| WT P. berghei NK65 | − | No ECM, 100% death by hyperparasitemia | ND |
| + | No ECM, 100% death by hyperparasitemia | ND | |
| KO P. berghei NK65 | − | No ECM, no death by hyperparasitemia, 100% survival | ND |
| + | ND | ND | |
a
†, death of mice; ND, not determined.