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Caps-PS antibody secretion by CD19+ CD5− and CD19+ CD5+ B cell subsets after vaccination with PPV23. CD19+ CD5+ B cells (2.5 × 104/well) and CD19+ CD5− B cells (2.5 × 104/well) obtained from a healthy adult at 7 days post-PPV23 vaccination were analyzed for their capacity to secrete anti-caps-PS serotype 4 antibodies by an ELISpot assay. ASC, antibody-secreting cells.
