Table 2.

Regions showing significant functional connectivity differences between adolescents with Internet addiction disorder (IAD) and matched control subjects (p < 0.05, AlphaSim corrected).

Seed	Seed	Regions of differences	Peak coordinates (MNI)			Peak T	Cluster size (voxels)
			X	Y	Z
Caudate	L VSi	Bilateral caudate head, subgenual ACC	6	6	0	−4.64	101
		Bilateral ventral PCC	6	−42	18	−4.34	33
	R VSi	Bilateral caudate head, subgenual ACC	−3	0	6	−5.79	99
	L VSs	Left putamen, pallidum, insula, IFG	−30	9	−3	−5.95	115
		Bilateral dorsal ACC	3	24	42	−4.89	78
		Bilateral ventroanterior thalamus	−6	−9	12	−4.71	74
		Bilateral rostral ACC	6	45	6	−4.25	35
	R VSs	Bilateral dorsal caudate, ventroanterior thalamus	−9	0	9	−5.84	112
		Right putamen/lentiform nucleus	30	−15	0	−5.00	35
		Bilateral dorsal ACC	0	36	33	−4.90	97
		Bilateral rostral ACC	9	33	9	−4.58	113
		Left putamen, pallidum, insula, IFG	−33	21	−9	−4.08	105
	L DC	Left ventrolateral thalamus	−18	−9	3	−4.40	36
		Right dorsal/rostral ACC	3	39	18	−4.34	251
	R DC	Right dorsal/rostral ACC	9	54	18	−4.75	114
		Left IFG	−27	24	−18	−4.70	31
		Bilateral dorsal ACC	−12	30	33	−4.56	112
Putamen	L DCP	Right caudal cigulate motor are	15	−21	45	4.90	42
		Left caudal cigulate motor are	−6	−21	48	4.57	26
	L VRP	Right IFG	51	15	12	−5.76	36

Note. Negative T values mean the functional connectivity of IAD is reduced while positive T values mean the functional connectivity of IAD is increased. Abbreviation: MNI, Montreal Neurological Institute; ACC, anterior cingulate cortex; PCC, posterior cingulate cortex; IFG, inferior frontal gyrus; L, left; R, right; VSi, inferior ventral striatum; VSs, superior ventral striatum; DC, dorsal caudate; DCP, dorsal caudal putamen; VRP, ventral rostral putamen.