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. 2015 Jun 16;9:157. doi: 10.3389/fnbeh.2015.00157

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Copyright © 2015 Varga, Herédi, Kánvási, Ruszka, Kis, Ono, Iwamori, Iwamori, Takakuwa, Vécsei, Toldi and Gellért.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of L-KYNs treatment on the number of c-Fos⁺ cells in the hippocampal CA1 area of C57Bl/6j mice. (A) Schematic illustration of the hippocampus. The red box (500 × 140 μm) indicates the captured and analyzed subregion of CA1. (B) Representative photomicrographs of c-Fos immunostaining in the CA1. There were a lower number of c-Fos⁺ cells in the L-KYNs-treated group (bottom panel) in comparison with the vehicle-treated group (top panel). Scale bars represent 50 μm. (C) Number of c-Fos⁺ cells in the CA1 area. The number of c-Fos⁺ cells was significantly reduced following L-KYNs administration. Data are shown as median, interquartile ranges ± minimum/maximum values (GLMM, ^*p ≤ 0.05; n = 20 animals).