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. 2015 Jul;88(1):141–150. doi: 10.1124/mol.114.097659

Fig. 3.

Fig. 3.

Amino acid side chains in the local anesthetic–binding site of NavAb. (A) Amino acid residues identified by mutagenesis of mammalian sodium channels and shown to be important in the drug block are illustrated as orange spheres. Helices S5 and S6 and the pore domain are depicted in a side view of the preopen state of NavAb. (B) Similar view to (A) showing the slow-inactivated state of NavAb. (C) NavAb is shown from the extracellular side. The S5 and S6 segments are shown as cylinders. Amino acid residues identified by mutagenesis of mammalian sodium channels and shown to be important in the drug block are illustrated as orange spheres. (D) Similar view to (C) showing the inactivated state of NavAb.