Fig. 2.
Signaling pathways associated with P2Y14R activation. The P2Y14R couples to Gi, thus promoting Gαi- and Gβγ-mediated inhibition of adenylyl cyclases 1, 3, 5, 6, 8, and 9. Additional direct and indirect effectors of Gβγ include K+ channels (GIRK), phosphatidylinositol 3-kinase-γ, GPCR kinase 2 and 3, and phospholipase C β2 and β3, P-rex1 Rac GEF, and SNAP-25. Rho, MAPKs, and potentially other effectors not listed represent examples of signaling proteins that are also activated downstream of Gβγ.