TABLE 2.
Proposed physiologic effects of P2Y14R activation
| P2Y14R-Associated Responses | References |
|---|---|
| Regulation of dendritic cell maturation | Skelton et al., 2003 |
| Inhibition of T-lymphocyte proliferation | Scrivens and Dickenson, 2005a |
| Recruitment of monocytes and macrophages in inflammation | Xu et al., 2012 |
| Stimulation of neutrophil chemotaxis | Sesma et al., 2012; Barrett et al., 2013 |
| Enhancement of degranulation of mast cells | Gao et al., 2013 |
| Promotion of hematopoietic regenerative responses | Cho et al., 2014 |
| Regulation of osteoclast differentiation | Lee et al., 2013; Kook et al., 2013a |
| Regulation of astrocyte remodeling | Kinoshita et al., 2013 |
| Stimulation of innate mucosal immunity in the female reproductive tract | Arase et al., 2009 |
| Promotion of lung inflammation | Muller et al., 2005 |
| Regulation of gastrointestinal muscle contraction and meal passage | Bassil et al., 2009; Meister et al., 2014 |
| Regulation of insulin secretion | Meister et al., 2014 |
| Regulation of smooth muscle contraction in some vascular beds | Meister et al., 2014; Haanes and Edvinsson, 2014a; Alsaqati et al., 2014 |