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. 2015 Jul;88(1):106–112. doi: 10.1124/mol.115.098822

Fig. 7.

Fig. 7.

Working model for CYP2D6 regulation in EE2-induced cholestasis. The working model illustrates the overlapping estrogen response element (ERE) and FXR response element (FXRE) in SHP promoter. In EE2-induced cholestasis, ERα recruitment to SHP promoter increases, leading to higher SHP expression. Also, cholestasis stabilizes SHP protein, further enhancing SHP expression. SHP in turn suppresses HNF4α transactivation of CYP2D6 promoter, leading to CYP2D6 repression in EE2-induced cholestasis.