TABLE 2.

Literature review of all studies reporting TR₄₆/Y121F/T289A A. fumigatus isolates^a

Reference	Date of isolation	Type of sample	Underlying condition(s)	Infection	Antifungal susceptibility MIC (mg/liter)b			Outcome	Country
					VRC	ITC	POS
1	July 2012	BAL fluid	HSCT	Probable IA	>16	4	1	Death	Belgium
2	December 2009	Sputum	HSCT	Probable IA	>16	4	0.25	Persistent infection	The Netherlands
	January 2010	Ear	Chronic otitis externals/sinusitis	IA	>16	>16	2	Persistent infection	The Netherlands
	January 2010	Abdominal abscess	SOT	Proven IA	>16	2	0.5	Death	The Netherlands
	February 2010	Sputum	Cystic fibrosis	No IA	>16	4	0.5	Survival	The Netherlands
	February 2010	Sputum	Lung carcinoma	No IA	>16	>16	2	Survival	The Netherlands
	March 2010	Sputum	HSCT	Probable IA	>16	1	0.25	Death	The Netherlands
	March 2010	Sputum	Cystic fibrosis, SOT	Proven IA	>16	>16	0.5	Survival	The Netherlands
	May 2010	Biopsy specimen	Chronic otitis, surgery	Proven IA	>16	4	1	Survival	The Netherlands
	May 2010	Sputum	Lung fibrosis	None	>16	>16	1	Survival	The Netherlands
	June 2010	Sputum	Traumatism	None	>16	1	0.25	Death	The Netherlands
	July 2010	Brain biopsy specimen	Beta thalassemia, diabetes mellitus	Proven IA	>16	4	1	Death	The Netherlands
	September 2010	Sputum	Cystic fibrosis	ABPA	>16	2	0.5	Survival	The Netherlands
	Oct 2010	Sputum	COPD, SOT	None	>16	>16	2	Survival	The Netherlands
	November 2010	Sputum	COPD	No IA	>16	>16	2	Survival	The Netherlands
	January 2011	Sputum	HSCT	Probable IA	>16	>16	1	Death	The Netherlands
	December 2009 to January 2011	Air sampling			ND	ND	ND		The Netherlands
8	2012–2013	Soil sampling			>16	1 to 2	0.25 to 0.5		India
3	September 2012	Sputum	Cystic fibrosis	Colonization	>8*	>8*	2*	Survival	Germany
4	January 2014	Sputum	Bruton's agammaglobulinemia, SOT	Probable IA	>4*	0.25 to 0.5*	0.125 to 0.25*	Death	Denmark
9	Not reported	Soil sampling			16 to >16	1 to 2	0.25 to 0.5		Tanzania
5	November 2013	BAL fluid	HSCT	Probable IA	>8	>16	1	Death	Belgium
7	September 2012	BAL fluid	HSCT	Probable IA	16*	>16*	0.5*	Death	Germany
	July 2012	BAL fluid	HSCT	Proven IA	1*	>16*	0.5*	Death	Germany
Present report	February 2013	Sputum	Cystic fibrosis	Colonization	>8*	>8*	ND	Survival	France
	March 2014	Sputum	Cystic fibrosis	Colonization	>8*	8*	ND	Survival	France

^aPOS, posaconazole; BAL, bronchoalveolar lavage; HSCT, hematopoietic stem cell transplantation; IA, invasive aspergillosis; SOT, solid-organ transplantation; ABPA, allergic bronchopulmonary aspergillosis; COPD, chronic obstructive pulmonary disease; ND, not determined.

^bData represent results determined using CLSI breakpoints, except those indicated with an asterisk, which represent results determined using EUCAST breakpoints.