TABLE 1.
MICs for NEO dimers 1 to 18 against B. cereus and various S. aureus strains
| Compound | MIC for strain: |
|||||||
|---|---|---|---|---|---|---|---|---|
| S. aureus USA 100 | S. aureus USA 200 | S. aureus USA 300 | S. aureus USA 600 | S. aureus ATCC 29213 | S. aureus ATCC 33591a | MRSA | B. cereus ATCC 11778 | |
| 1 (NEO) | >50 | >50 | >50 | >50 | 3.13 | 159.5 | >50 | 1.56 |
| 2 | >50 | >50 | >50 | >50 | 1.56 | >44.4 | >50 | 12.5 |
| 3 | >50 | >50 | >50 | >50 | 3.13 | 43.2 | >50 | 12.5 |
| 4 | >50 | >50 | >50 | >50 | 6.25 | >42.6 | >50 | 25 |
| 5 | >50 | >50 | >50 | >50 | 3.13 | 20.1 | >50 | 25 |
| 6 | >50 | >50 | >50 | >50 | 1.56 | >44.2 | >50 | 25 |
| 7 | >50 | >50 | >50 | >50 | 3.13 | >41.2 | >50 | >25 |
| 8 | 25 | 25 | 25 | 25 | 3.13 | 20.1 | 25 | 25 |
| 9 | >50 | 50 | >50 | >50 | 3.13 | >43.6 | >50 | 12.5 |
| 10 | >50 | >50 | >50 | >50 | >50 | >41.7 | >50 | >25 |
| 11 | >50 | >50 | >50 | >50 | >50 | >43.8 | >50 | >25 |
| 12 | >50 | >50 | >50 | >50 | 12.5 | >43.8 | >50 | >25 |
| 13 | >50 | >50 | >50 | >50 | 25 | >46.9 | >50 | >25 |
| 14 | >50 | >50 | >50 | >50 | 3.13 | 43.9 | >50 | 12.5 |
| 15 | >50 | 50 | >50 | >50 | 3.13 | >42.2 | 50 | 6.25 |
| 16 | >50 | >50 | >50 | >50 | >50 | 20 | >50 | >25 |
| 17 | >50 | 25 | >50 | >50 | 3.13 | >27.3 | >50 | 25 |
| 18 | 25 | 25 | 25 | 50 | 3.13 | >39.7 | 12.5 | >25 |
a
The data for these S. aureus isolates were previously reported in reference 17. They have been included as the resistance enzymes for this strain and were probed by PCR (see Fig. 4).