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Estimated IC50s of cefoxitin for PAO1 and PAO ΔampC PBPs using Bocillin FL test
| Strain or mutant | IC50 of FOX (μg/ml) fora: |
||||||
|---|---|---|---|---|---|---|---|
| PBP1a | PBP1b | PBP2 | PBP3 | PBP4 (DacB) | PBP5 (DacC) | PBP7 (PbpG) | |
| PAO1 | 6.4 | 30.7 | 16.4 | 8 | 1.5 | 9.1 | <1.5 |
| PAO ΔampC | 4.8 | 27.2 | 15.4 | 7.7 | 1.3 | 6.5 | <1.5 |
Cefoxitin (FOX) concentration producing a 50% reduction in Bocillin FL binding for each individual PBP.
