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. 2015 Jun 12;59(7):4003–4011. doi: 10.1128/AAC.04917-14

FIG 2.

FIG 2

Photodynamic inhibition of Paracoccidioides spp. (A) Determination of the optimal concentration of TBO. C1, control; C2, 90 J/cm2 LED; C3, 10 mg/liter TBO; C4, 40 mg/liter TBO; C5, 70 mg/liter TBO; T1, 10 mg/liter TBO plus 90 J/cm2 LED; T2, 40 mg/liter TBO plus 90 J/cm2 LED; T3, 70 mg/liter TBO plus 90 J/cm2 LED. (B) Determination of the optimal energy density of LED at 630 nm. C1, control; C2, 40 mg/liter TBO; C3, 30 J/cm2 LED; C4, 60 J/cm2 LED; C5, 90 J/cm2 LED; T1, 40 mg/liter TBO plus 30 J/cm2 LED; T2, 40 mg/liter TBO plus 60 J/cm2 LED; T3, 40 mg/liter TBO plus 90 J/cm2 LED. (C) Numbers of nonmelanized and melanized Paracoccidioides species strains after aPI. *, statistically significant difference in comparison with the control for each aPI treatment (P < 0.0001); #, statistically significant difference in comparison to nonmelanized cells subjected to aPI (P < 0.05). C, growth control; mel−, nonmelanized cells; mel+, melanized cells. The error bars indicate SEM.