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MICs of itraconazole and amphotericin B against nonmelanized and melanized P. brasiliensis yeasts
| Isolate | MICa (mg/liter) |
|||
|---|---|---|---|---|
| Itraconazole |
Amphotericin B |
|||
| Mel− | Mel+ | Mel− | Mel+ | |
| Pb 18 | 0.0039 | 0.125 | 1.0 | 2.0 |
| Pb 05 | 0.015 | 12.0 | 1.0 | 14.0 |
| Pb 08 | 0.062 | 0.125 | 1.0 | 4.0 |
MICs for nonmelanized (Mel−) cells were demonstrated by Cruz et al. (24) according to a modified CLSI protocol. Mel+, melanized cells cultured in l-DOPA medium.
