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In vitro development of azole resistance and its reversion by ibuprofen
| Strain | MIC (μg/ml)/phenotype fora: |
|||||
|---|---|---|---|---|---|---|
| FLC | FLC + Ibu | VRC | VRC + Ibu | PSC | PSC + Ibu | |
| CaS | 1/S | 1/S | 0.06/S | 0.06/S | 0.03/S | 0.06/S |
| CaR | >64/R | 2/S | >8/R | 0.06/S | >8/R | 0.125/R |
MICs to azoles, namely, fluconazole (FLC), voriconazole (VRC), and posaconazole (PSC), alone and in combination with subinhibitory concentration of ibuprofen (Ibu) (100 μg/ml). S, susceptible; R, resistant.
