TABLE 2.
Daptomycin and vancomycin MICs and thickness of cell wall sacculi of DapS and DapNS strain pairs
| DapS/DapNS strain pair | MIC (μg/ml) |
Cell wall sacculus thickness (nm) | ||
|---|---|---|---|---|
| Daptomycin |
Vancomycin (broth microdilution) | |||
| Etest | Broth microdilution | |||
| 616/703a | 0.094/1.5 | 0.5/2 | 0.5–1/0.5–1 | 16.3 ± 2.0/21.8 ± 2.2 |
| Q2819/Q2818a | 0.094/1–1.5 | 0.5/2 | 0.5–1/1 | 19.5 ± 2.1/19.7 ± 2.3c |
| BOY755/BOY300b | 0.094/1–1.5 | 0.5/2 | 1/1 | 19.9 ± 3.8/21.6 ± 0.9 |
| CB5011/CB5012 | 0.094/5 | 0.5/2 | 0.5/1 | 21.3 ± 2.3/24.6 ± 3.1 |
| CB5062/CB5063 | 0.094/2 | 0.5/4 | 0.5/1 | 20.4 ± 3.1/21.9 ± 1.5 |
| CB1663/CB1664 | 0.125/3 | 0.5/4 | 0.5–1/2–4 | 21.2 ± 2.1/31.4 ± 4.1 |
a
Patients were treated with vancomycin prior to daptomycin treatment.
b
No vancomycin treatment of the patient because of allergies.
c
Not significant. All other strain pairs have P values of < 0.05.