FIG 3.

Subdermal implantation of TAF LA prototype device in beagle dogs maintains sustained drug levels with low systemic exposure to TAF and TFV with concomitant, efficient PBMC loading with TFV-DP. Pharmacokinetic profiles of plasma TAF (closed circles) and TFV (open circles) and PBMC TFV-DP (closed diamonds). Each data point represents the means ± standard deviations from four beagle dogs, and dotted lines correspond to the median concentrations for each analyte over the 40-day study. Note that TFV-DP levels were measured only after day 20.