TABLE 1.
Genotype, allele, and haplotype distributions of NAT1 and NAT2 in patients with tuberculosis randomized in a crossover study to receive either 4 g granular slow-release para-aminosalicylic acid twice daily or 8 g once daily
| Allele, genotype, or haplotype | Count (frequency) by race |
Count (frequency) by gender |
HWEa |
|||||
|---|---|---|---|---|---|---|---|---|
| All | Mixed | Black | P value | Male | Female | P value | P value | |
| NAT1 | ||||||||
| Typed | 32 | 27 | 5 | 18 | 14 | |||
| Allele | 0.92 | |||||||
| 1*4 | 23 (0.71) | 19 (0.70) | 4 (0.80) | 13 (0.72) | 10 (0.71) | |||
| 1*10 | 22 (0.68) | 18 (0.66) | 4 (0.80) | 10 (0.56) | 12 (0.86) | |||
| 1*14A | 2 (0.06) | 2 (0.07) | 2 (0.11) | |||||
| 1*3 | 1 (0.03) | 1 (0.04) | 1 (0.07) | |||||
| Unknown | 1 (0.03) | 1 (0.03) | 1 (0.06) | |||||
| Genotype | 0.770 | 0.172 | ||||||
| 1*4/1*4 | 7 (0.22) | 6 (0.22) | 1 (0.20) | 5 (0.28) | 2 (0.14) | |||
| 1*4/1*10 | 14 (0.44) | 11 (0.41) | 3 (0.60) | 6 (0.33) | 8 (0.57) | |||
| 1*10/1*10 | 7 (0.22) | 6 (0.22) | 1 (0.20) | 4 (0.22) | 3 (0.21) | |||
| 1*4/1*14A | 2 (0.06) | 2 (0.07) | 2 (0.11) | |||||
| 1*10/1*3 | 1 (0.03) | 1 (0.04) | 1 (0.07) | |||||
| NAT2 | ||||||||
| Typed | 32 | 27 | 5 | 18 | 14 | |||
| Allele | 0.76 | |||||||
| 2*4 | 21 (0.66) | 18 (0.67) | 3 (0.60) | 12 (0.67) | 9 (0.64) | |||
| 2*6 | 11 (0.34) | 7 (0.26) | 4 (0.80) | 7 (0.39) | 4 (0.29) | |||
| 2*5 | 12 (0.38) | 10 (0.37) | 2 (0.40) | 7 (0.39) | 5 (0.36) | |||
| 2*3 | 4 (0.13) | 4 (0.15) | 1 (0.06) | 3 (0.21) | ||||
| 2*14 | 2 (0.6) | 2 (0.07) | 2 (0.14) | |||||
| Genotype | 0.046 | 0.169 | ||||||
| 2*4/2*4 | 7 (0.22) | 7 (0.26) | 4 (0.22) | 3 (0.21) | ||||
| 2*4/2*6 | 5 (0.16) | 3 (0.11) | 2 (0.40) | 3 (0.17) | 2 (0.14) | |||
| 2*4/2*5 | 7 (0.22) | 6 (0.22) | 1 (0.2) | 4 (0.22) | 3 (0.21) | |||
| 2*4/2*3 | 1 (0.03) | 1 (0.04) | 1 (0.06) | |||||
| 2*4/2*14 | 1 (0.03) | 1 (0.04) | 1 (0.07) | |||||
| 2*6/2*6 | 3 (0.09) | 2 (0.07) | 1 (0.20) | 3 (0.17) | ||||
| 2*6/2*5 | 1 (0.03) | 1 (0.20) | 1 (0.06) | |||||
| 2*6/2*3 | 3 (0.09) | 3 (0.11) | 3 (0.21) | |||||
| 2*5/2*5 | 3 (0.09) | 3 (0.11) | 2 (0.11) | 1 (0.07) | ||||
| 2*5/2*14 | 1 (0.03) | 1 (0.04) | 1 (0.07) | |||||
| NAT1/NAT2 haplotype | 0.022 | 0.436 | ||||||
| 1*10/2*6 | 9 (0.28) | 6 (0.22) | 3 (0.60) | 5 (0.28) | 4 (0.29) | |||
| 1*4/2*6 | 8 (0.25) | 4 (0.15) | 4 (0.80) | 5 (0.28) | 3 (0.21) | |||
| 1*10/2*14 | 2 (0.06) | 1 (0.04) | 1 (0.20) | 2 (0.14) | ||||
| 1*14A/2*5 | 1 (0.03) | 1 (0.04) | 1 (0.06) | |||||
| 1*14A/2*3 | 1 (0.03) | 1 (0.04) | 1 (0.06) | |||||
| 1*3/2*14 | 1 (0.03) | 1 (0.04) | 1 (0.07) | |||||
| 1*4/2*5 | 7 (0.22) | 6 (0.22) | 1 (0.20) | 4 (0.22) | 3 (0.21) | |||
| 1*10/2*5 | 8 (0.25) | 7 (0.26) | 1 (0.20) | 5 (0.28) | 3 (0.21) | |||
| 1*10/2*3 | 3 (0.09) | 3 (0.11) | 3 (0.21) | |||||
| 1*4/2*4 | 16 (0.50) | 14 (0.52) | 2 (0.20) | 9 (0.50) | 7 (0.50) | |||
| 1*10/2*4 | 13 (0.41) | 11 (0.41) | 2 (0.20) | 5 (0.28) | 8 (0.57) | |||
| 1*4/2*3 | 3 (0.09) | 3 (0.11) | 1 (0.06) | 2 (0.14) | ||||
| 1*4/2*14 | 1 (0.03) | 1 (0.04) | 1 (0.07) | |||||
a
HWE, Hardy-Weinberg equilibrium.