FIG 3.

Romidepsin significantly inhibits HIV replication in primary CD4⁺ T cells. (A) Schematic representation of the experimental approach. (B) Delayed HIV replication kinetics in activated CD4⁺ T cells observed after 40 nM romidepsin treatment from five human donors (means ± the standard errors of the mean). (C) From the curves in panel B, the AUC was calculated for each indicated time. AUC values for each condition and donor were normalized to the medium only control of each respective donor. *, P < 0.05; **, P < 0.001; ***, P < 0.0001.