TABLE 5.
Gene enrichment analysis of P. aeruginosa biofilms treated with antibiotics compared to untreated biofilms based on Gene Ontology groups
| Gene Ontology term | Gene count | P value |
|---|---|---|
| Upexpressed in biofilms by ciprofloxacin | ||
| Non-membrane-bound organelle | 5 | 8.3 × 10−5 |
| Cytolysis | 3 | 1.9 × 10−3 |
| SOS response | 3 | 8.0 × 10−4 |
| Downexpressed in biofilms by ciprofloxacin | ||
| Arginine metabolic process | 3 | 3.1 × 10−5 |
| Heme binding | 4 | 1.2 × 10−3 |
| Upexpressed in biofilms by tobramycin | ||
| Ribosome | 12 | 3.2 × 10−13 |
| RNA binding | 11 | 2.8 × 10−7 |
| RNA processing | 9 | 7.1 × 10−5 |
| SOS response | 3 | 4.2 × 10−3 |
| Downexpressed in biofilms by tobramycin | ||
| Generation of precursor metabolites for energy | 12 | 5.8 × 10−10 |
| TCA cycle | 5 | 7.8 × 10−5 |
| Glycolysis/gluconeogenesis | 5 | 1.7 × 10−4 |
| Cellular respiration | 5 | 8.9 × 10−4 |
| Arginine metabolic process | 3 | 8.0 × 10−3 |