TABLE 7.

Antibiotic susceptibility of selected P. aeruginosa mutants in biofilms

Strain/mutant	Locus	LR with CIPa	Pb	LR with TOBa	Pb	Xoa,c (log10 CFU cm−2)
MPAO1	WTd	0.9 ± 0.3		0.6 ± 0.2		9.8 ± 0.2
anr mutant	PA1544	2.6 ± 0.3	0.001	0.3 ± 0.4	0.52	8.8 ± 0.2
rpoS mutant	PA3622	2.9 ± 0.9	0.027	0.6 ± 0.3	0.96	10.1 ± 0.3
relA spoT mutant	PA0934, PA5338	2.4 ± 0.4	0.003	0.9 ± 0.4	0.30	9.9 ± 0.2
mvfR mutant	PA1003	1.2 ± 0.5	0.46	NDe		9.5 ± 0.4
brlR mutant	PA4878	ND		0.4 ± 0.4	0.54	9.8 ± 0.1
lasI rhlI mutant	PA1432, PA3476	1.7 ± 0.4	0.07	0.5 ± 0.4	0.95	8.9 ± 0.2

^aUncertainty estimates are the standard deviations. LR, log reduction.

^bP values are for the comparison to the log reduction measured for the wild type.

^cX_o, areal cell density of untreated biofilms.

^dWT, wild type.

^eND, not determined.