FIG 5.

Median fractional arylomycin A-C₁₆ MICs as a function of increasing PMBN concentrations at 37°C and 28°C for Y. pestis KIM5 and KIM5-pLpxL. The arylomycin A-C₁₆ MICs in the absence of PMBN were 4 μg/ml (37°C) and 16 μg/ml (28°C) for KIM5 and 8 μg/ml (37°C) and 16 μg/ml (28°C) for KIM5-pLpxL. The fractional arylomycin A-C₁₆ MIC is equal to the MIC of arylomycin A-C₁₆ in the presence of the tested PMBN concentration divided by the MIC of arylomycin A-C₁₆ alone. The shading of the bars indicates the PMBN concentration tested (1 to 64 μg/ml in a 2-fold dilution series).