TABLE 1.

Pharmacokinetic parameters of valnemulin in serum following single-dose intramuscular administration various doses in M. gallisepticum infected chickens (n = 10/group)

Parametera	Results for valnemulin dose (mg/kg) of:
	1	10	20
Cmax (μg/ml)	6.34	71.32	111.13
Tmax (h)	0.5	0.5	0.5
t1/2β (h)	2.78	2.81	2.71
AUC24 (μg · h/ml)	13.88	125.96	213.61
CLβ/F (liters/h/kg)	0.072	0.079	0.093
Vz/F (liters/kg)	0.29	0.32	0.36

^aC_max, maximum serum concentration; T_max, time of maximum serum concentration; t_1/2β, elimination half-life; AUC₂₄, 24-h area under serum concentration-time curve; F, bioavailability; CL_β/F, clearance divided by bioavailability; V_z/F, volume of distribution scaled by bioavailability.