TABLE 2.
Lung CFU counts in BALB/c and C3HeB/FeJ mice at the beginning of treatment (day 0) and after 1, 2, 3, or 4 months of treatment with the indicated regimens
| Mouse strain and treatment | Log10 CFU ± SD at various time pointsa |
|||||||
|---|---|---|---|---|---|---|---|---|
| JHU |
CSU |
|||||||
| D0 | M1 | M2 | D0 | M1 | M2 | M3 | M4 | |
| BALB/c | 7.46 ± 0.40 | 5.62 ± 0.25 | ||||||
| RIF-INH-PZA-EMB | 3.87 ± 0.05 | 1.98 ± 0.26 | 2.29 ± 0.26 | 0.00 ± 0.00 | 0.07 ± 0.16 | 0.00 ± 0.00 | ||
| RIF-INH-PZA-MXF | 3.62 ± 0.24 | 1.65 ± 0.37 | 1.40 ± 0.27 | 0.08 ± 0.18 | 0.00 ± 0.00 | |||
| RIF-MXF-PZA-EMB | 3.12 ± 0.24 | 0.99 ± 0.42 | 1.86 ± 0.56 | 0.50 ± 0.48 | 0.22 ± 0.49 | |||
| C3HeB/FeJ | 8.83 ± 0.55 | 6.70 ± 1.21 | ||||||
| RIF-INH-PZA-EMB | 3.43 ± 0.17 | 1.09 ± 0.38 | 2.04 ± 1.03 | 0.48 ± 0.07 | 0.12 ± 0.29 | 0.50 ± 0.58 | ||
| RIF-INH-PZA-MXF | 2.92 ± 0.20 | 0.63 ± 0.66 | 3.86 ± 0.86 | 0.08 ± 0.18 | 0.00 ± 0.00 | |||
| RIF-MXF-PZA-EMB | 2.90 ± 0.38 | 0.48 ± 0.92 | 4.60 ± 0.45 | 0.00 ± 0.00 | 0.00 ± 0.00 | |||
a
D0, day 0; M1, month 1, etc.