TABLE 3.

Final population PK model parameter estimates

Parameter	Point estimate	% RSEa	Bootstrap CIb
			2.5%	Median	97.5%
Fixed effects
V (liters/kg)	0.93	5.8	0.83	0.93	1.06
CL (liters/h/kg)	0.019	5.6	0.017	0.019	0.021
Coefficient for ECMO on V	1.39	7.8	1.17	1.39	1.63
Exponent for creatinine on CL	−0.29	9.9	−0.41	−0.29	−0.24
Random effects
V interindividual variability (CV [%])c	22.2	28.6	14.7	21.5	27.7
CL interindividual variability (CV [%])	33.2	21.3	25.0	32.6	39.2
Residual proportional error (CV [%])	15.3	13.1	13.0	15.2	16.9

^aRSE, residual standard error.

^bCI, confidence interval.

^cCV, coefficient of variation.