TABLE 5.

Exposure in children on ECMO after different simulated dosing regimens

Indication	Loading dose (mg/kg)	Maintenance dose (mg/kg)	Dosing interval (h)	% children for whom PD target was achieved in first 24 ha	Time to therapeutic exposure (days)a
Treatment		12	q24	0	10
	25	12	q24	34.0	8
	35	12	q24	87.7	2
	40	12	q24	95.4	1
	25 q12h	12	q24	90.8	1
Prophylaxis		6	q24	0	7
	12	6	q24	27.8	5
		12	q72	27.8	—b
		25	q168	99.9	—

^aPD, pharmacodynamics. The PD target for treatment/therapeutic exposure is an AUC₂₄ of >400 mg · h/liter in 90% of the simulated children. The PD target for prophylaxis is an AUC₂₄ of >200 mg · h/liter in 90% of the simulated children.

^b—, for q72h and q168h dosing, we set the target as an AUC₂₄ of >200 mg · h/liter in 90% of the simulated children for each 24-h period during the dosing interval. Using this approach, 90% of the simulated children never maintained an AUC₂₄ of >200 mg · h/liter for each 24-h period.