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(A) Timed inactivation of SHV-1 by increasing concentrations of avibactam. (B) Timed inactivation of SHV S130G by increasing concentrations of avibactam. The SHV S130G variant takes longer to plateau because of the lower NCF catalytic efficiency of this enzyme. An approximately 1,700-fold-higher concentration of avibactam was required to inhibit the SHV S130G variant compared to SHV-1.
