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. 2015 May;10(5):677–678. doi: 10.4103/1673-5374.156942

Figure 1.

Figure 1

A Syd-1/Liprin-α/Wrd phosphatase pathway and a GSK-3β kinase pathway converge to regulate active zone stability.

The active zone (AZ) organizers Syd-1 and Liprin-α collaborate to localize a Wrd-containing protein phosphatase 2A (PP2A) phosphatase complex to the AZs, where it dephosphorylates specific substrates to promote AZ stability. A GSK-3β signaling pathway antagonizes the action of the Syd-1/Liprin-α/Wrd phosphatase pathway directly via phosphorylating the Wrd substrates, or indirectly via its downstream targets. GSK-3β: Glycogen synthase kinase-3beta.