Table 3.
Multivariatea-adjusted geometric mean and 95% confidence interval (CI) for percent dense breast volume by quartiles of androgens and SHBG at pre-b and postmenarchealb periods
| Quartiles | Premenarche | Postmenarche | All periods | |||
|---|---|---|---|---|---|---|
| Mean | (95 % CI) | Mean | (95 % CI) | Mean | (95 % CI) | |
| Androstenedione | N = 153 | N = 154 | N = 174 | |||
| Q1 | 20.2 | (17.2-23.7) | 17.9 | (14.6-22.1) | 19.2 | (16.5-22.3) |
| Q2 | 18.8 | (14.9-23.8) | 19.4 | (14.8-25.5) | 19.2 | (14.7-24.9) |
| Q3 | 18.1 | (13.5-24.1) | 18.0 | (14.4-22.3) | 18.0 | (15.2-21.3) |
| Q4 | 17.4 | (11.0-27.6) | 17.9 | (13.7-23.5) | 18.6 | (14.1-24.6) |
| P-trendc | 0.30 | 0.88 | 0.69 | |||
| DHEAS | N = 153 | N = 156 | N = 176 | |||
| Q1 | 16.7 | (12.7-22.0) | 19.9 | (13.6-29.1) | 18.7 | (14.2-24.5) |
| Q2 | 19.6 | (14.2-26.9) | 16.3 | (12.1-22.1) | 17.5 | (14.6-20.9) |
| Q3 | 16.6 | (13.2-20.9) | 17.0 | (14.5-20.0) | 17.5 | (15.1-20.3) |
| Q4 | 22.1 | (17.3-28.0) | 20.3 | (17.9-22.9) | 21.5 | (18.2-15.4) |
| P-trendc | <0.001 | 0.84 | 0.10 | |||
| Testosterone | N = 150 | N = 156 | N = 175 | |||
| Q1 | 17.6 | (14.8-20.9) | 16.7 | (14.1-19.7) | 18.5 | (15.2-22.6) |
| Q2 | 20.5 | (18.4-22.7) | 18.6 | (14.8-23.3) | 19.2 | (16.3-22.7) |
| Q3 | 18.0 | (12.0-26.9) | 18.2 | (12.5-26.4) | 18.7 | (14.7-23.8) |
| Q4 | 17.7 | (11.5-27.2) | 19.8 | (17.4-22.6) | 18.2 | (14.1-23.6) |
| P-trendc | 0.90 | 0.16 | 0.87 | |||
| SHBG | N = 153 | N = 156 | N = 176 | |||
| Q1 | 14.4 | (10.2-20.4) | 15.7 | (11.0-22.6) | 15.5 | (12.8-18.7) |
| Q2 | 18.7 | (15.3-22.8) | 17.1 | (12.9-22.7) | 17.5 | (13.3-23.1) |
| Q3 | 18.3 | (14.6-22.9) | 25.0 | (18.0-24.6) | 22.1 | (20.2-24.2) |
| Q4 | 24.3 | (19.6-30.1) | 16.7 | (14.8-18.8) | 20.5 | (15.6-26.9) |
| P-trendc | 0.03 | 0.42 | 0.05 | |||
Abbreviations: CI confidence interval, DHEAS, dehydroepiandrosterone sulfate; SHBG, sex hormone-binding globulin
aGeometric means and 95 % CI are estimated from linear mixed-effects models including clinic as a random effect and adjusted for treatment group (diet intervention group, usual-care control group, BMI (kg/m2, continuous), parity (0 and >0), duration of hormone use (yrs, continuous), race (white and nonwhite), and education (bachelor's degree, graduate school and other) as fixed effects
bThe androgens and SHBG levels were standardized by adjusting for age at visit, BMI z-score at visit, and visit number in years after randomization by residual method
c P-test for trend was conducted by modeling the quartile medians of standardized hormone concentrations as a continuous term in linear mixed-effects models and calculating the Wald test statistic