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. 2015 Jun 16;5:11373. doi: 10.1038/srep11373

Figure 4. miR-21 played an important role in bystander micronucleus formation in WS1 cells co-cultured with α-irradiated HaCaT cells.

Figure 4

Panel a, the alterations of miR-21 of HaCaT cells after α- and X-irradiation. Panel b, overexpression of miR-21 in HaCaT cells 24 and 72 h after miR-21 mimic transfection. Panel c, the effect of overexpression of miR-21 in HaCaT cells by miR-21 mimic transfection on the bystander micronucleus formation in unirradiated WS1 cells. Panel d, downregulation of miR-21 in HaCaT cells 24 and 72 h after miR-21 inhibitor transfection. Panel e, downregulation of miR-21 in HaCaT cells alone induced bystander-like effect in WS1 cells after co-culture. * P < 0.05, **P < 0.01 and *** P < 0.001 compared with the relative control.