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. 2015 Jun 16;6:592. doi: 10.3389/fmicb.2015.00592

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Copyright © 2015 Ou, Zhang, Wu, Shi and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapeutic efficacy of dryocrassin ABBA in mice infected with influenza virus A/Chicken/Hebei/706/2005. (A) The mice survival rate post administration with 33, 18, 12.5 mg/kg of dryocrassin ABBA or 20 mg/kg of amantadine hydrochloride. The infection control group was inoculated with H5N1 virus without any medication. (B) The assessment of mouse body weight post administration with dryocrassin ABBA or amantadine hydrochloride as compared to the untreated or control animals on Day 7 and 14. ^∗∗ Indicates a statistically significant differences (P < 0.01) in body weight when the untreated group was compared with drug-treated groups on day 7 or 14.