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. 2015 Jun 16;9:218. doi: 10.3389/fnins.2015.00218

Figure 3.

Figure 3

Small Molecule inhibition of MRP1 and chemoresponse in Primary GBM tumor derived cell lines. (A) Treatment of primary tumor-derived GBM cell lines, MZ-327, and MZ-18, led to a significant increase in both vincristine and etoposide-induced cell death compared to chemotherapy treatment alone (n = 3 *p < 0.05, **p < 0.01, ***p < 0.001 Unpaired Student T-test). The presence of MK571 (25 μM) did not have any effect on temozolomide–induced cell death in either of these cell lines. Treatment with Reversan (15 μM) significantly increased cell death for all three chemotherapies tested (n = 3 *p < 0.05, **p < 0.01 Unpaired Student T-test) in both lines assessed (B) relative to single chemotherapy drug treatment.