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. 2015 Jun 16;9:218. doi: 10.3389/fnins.2015.00218

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Copyright © 2015 Tivnan, Zakaria, O'Leary, Kögel, Pokorny, Sarkaria and Prehn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of MK571 and Reversan on cell proliferation and 2D-migration in commercial, primary, and recurrent GBM cell lines. Glioblastoma cells U251 (A), MZ-327 (C), and MZ-256 (E) were pre-incubated with non-specific MRP1 small molecule inhibitors MK571 (25 μM) or Reversan (15 μM) and proliferation and wound-closure capabilities assessed. No significant change in proliferation was noted in any of the representative cell lines assessed. Similarly, treatment of glioblastoma cell lines with Reversan does not alter cell motility in commercial (B), primary (D) and recurrent (F) GBM cells.