Skip to main content
. 2014 Apr 17;2014(4):CD008998. doi: 10.1002/14651858.CD008998.pub2

Skarbinski 2009 KEN.

Methods Cluster RCT; randomized by health facilities
Stratified random selection of facilities, by transmission settings (high/low) and facility type (hospitals, health centres and dispensaries)
Took into account a design effect of two in sampling
Reference slide taken. Results not reported
Trial lasted four months
Participants Inclusion: age ≥ 5 years, irrespective of condition
Number of participants randomized: Intervention arm: 799
Number analysed for primary outcome (prescribing of antimalarials): 669 (16.3% loss)
Interventions Intervention: RDTs for fever patients ≥ 5 years
Control: Presumptive treatment of fever
Boh groups received training and held guidelines
RDT performed by health workers
Health workers complied with guidelines partially: 41% of participants with negative RDT results received antimalarials
Outcomes Primary outcomes:
  1. Fever patients prescribed ACT

  2. Microscopy negative patients prescribed ACT


Secondary outcomes:
  1. RDT negative patients prescribed ACT; and RDT positive patients prescribed ACT

  2. Patients prescribed ACT presumptively

  3. Patients with known alternative diagnosis receiving ACT

Notes Country: Kenya
RDT: paracheck
Setting: all referral levels of facilities, 60 in total, 30 in each arm
Transmission: Hyperendemic or holoendemic at some sites and low and seasonal at others.
Dates: June to September 2006
Funding: USAID
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) High risk Systematic allocation.
Allocation concealment (selection bias) Unclear risk Although probabilistic sampling was used in selecting the participating health facilities, the participants had foreknowledge of intervention assignments.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Both the trial participants and personnel were aware of intervention allocation.
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Both the trial participants and personnel were aware of the diagnoses and prescriptions.
Incomplete outcome data (attrition bias) 
 All outcomes High risk Per protocol analysis; loss to follow‐up was high, more at the intervention facilities (20.2%) than at the control facilities (11.2%).
Selective reporting (reporting bias) Low risk Reported on all pre‐specified outcomes (prescribing of ACT); did not explicitly report on overall antimalarial prescribing, but the summary data were available for inclusion in the review.
Other bias Low risk Baseline imbalance minimised by stratifying facilities by level and randomly selecting within each level.
Summary data were adjusted for baseline imbalance.
Results could be biased towards the null, because some facilities in the comparison arms had RDT.
Loss of complete clusters: not reported.