1. Overview of studies conducted in areas of low endemicity.

Study ID	Design	Country	Year	Endemicity	MDA group						Control group/ Baseline
					Drug (dose)	Interval	No. of rounds	Population targeted	Coverage	Co‐intervention
Shekalaghe 2011	CRT	Tanzania	2008	0%*	AS (4 mg/kg/day for 3 days) +SP (25 mg/1.25 mg on day 1) +PQ (0.75 mg on day 3)	‐	1	1110	93%	Background ITN use	Placebo + Background ITN use
Malaria_Taiwan 1991	BAS	Taiwan	1955	3‐4%*	CQ (12 mg/kg)	‐	1	1520	ND	IRS	IRS

CRT = Cluster‐randomized trial; BAS = Uncontrolled before‐and‐after study; AS = Artesunate; SP = Sulfadoxine‐Pyrimethamine; PQ = Primaquine; CQ = Chloroquine; ND = Not described; IRS = Indoor Residual Spraying.

*In all ages