De Zulueta 1961 UGA.
Methods | Dates of study: 1959‐1960 Location of study: Uganda Malaria endemicity (prevalence): 34% in children 2‐9 years; 17% in all ages [Moderate] Transmission season: Rainy season April to May, August to November Malaria species: P. falciparum, P. malariae Vector species: A. gambiae, A. funestus Study design: Uncontrolled before‐and‐after study Evaluation design: Cross‐sectional surveys |
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Participants | Age groups included: All ages Sample size Intervention group 1 mean (range): 30,384 (10,303 ‐ 59,605) |
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Interventions | Intervention group 1 (North Kigezi): MDA administered to all persons with chloroquine 600 mg and pyrimethamine 50 mg every three months for four rounds at the time of IRS application from May 1959 to May 1960. Coverage 80%. Co‐intervention with IRS. | |
Outcomes | Parasitaemia prevalence Gametocytaemia prevalence No adverse event surveillance conducted No adverse events reported |
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Notes | Outcomes assessed in a sub‐sample of the treated population. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | High risk | No comparison group |
Allocation concealment (selection bias) | High risk | No comparison group |
Baseline imbalance (selection bias) | High risk | No comparison group |
Contamination protection | High risk | No comparison group |
Blinding of participants and personnel (performance bias) All outcomes | High risk | No comparison group |
Blinding of outcome assessment (detection bias) All outcomes | High risk | No comparison group |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Cooperation of the local inhabitants was remarkably good and not a single dwelling was left unsprayed |
Selective reporting (reporting bias) | Low risk | Increased number of samples from hyperendemic areas in the post‐intervention survey |
Other bias | Low risk | No other bias detected |