Study	Reason for exclusion
Abraham 1944	Inadequate treatment dose
Afridi 1959	Inadequate treatment dose
Ahorlu 2009	Treatment not administered to entire population; intermittent preventive treatment for children (IPTc) study
Ahorlu 2011	Treatment not administered to entire population; intermittent preventive treatment for children (IPTc) study
Aikins 1993	Inadequate treatment dose; knowledge, attitudes, and prevention component of an individually randomized study
Alicata 1955	Inadequate treatment dose; individually randomized study
Aliev 2000	Inadequate treatment dose
Aliev 2001	Inadequate treatment dose
Allen 1990	Inadequate treatment dose
Alonso 1993a	Inadequate treatment dose; individually randomized study
Alonso 1993b	Inadequate treatment dose; individually randomized study
Alving 1952	Individually randomized study; study participants did not remain in endemic area
Amangel'diev 2001	Inadequate treatment dose; testing conducted prior to treatment; insufficient information on drug administration
Annual Report 1932	Inadequate treatment dose
Archambeault 1954	Study participants did not remain in endemic area
Archibald 1956	Individually randomized study
Babione 1966	Insufficient information on drug administration
Banerjea 1949	Inadequate treatment dose
Barber 1932	Inadequate treatment dose
Barger 2009	Individually randomized study
Baukapur 1984	Insufficient information on drug administration
Berberian 1948	Testing conducted prior to treatment
Berny 1936	Inadequate treatment dose
Bloch 1982	Insufficient information on drug administration
Bojang 2009	Insufficient information on outcomes reported
Bojang 2010	Individually randomized study
Bojang 2011	Insufficient information on outcomes reported
Boulanger 2009	Individually randomized study
Boulanger 2010	Individually randomized study
Brink 1958	Inadequate treatment dose
Butler 1943	Insufficient information on drug administration
Canet 1936	Inadequate treatment dose
Canet 1939	Insufficient information on outcomes reported
Canet 1949	Insufficient information on drug administration; insufficient information on outcomes reported (no outcome of interest reported)
Canet 1952	Inadequate treatment dose
Canet 1953	Inadequate treatment dose
Capponi 1953	Inadequate treatment dose
Celli 1914	Insufficient information on drug administration
Charles 1958	Individually randomized study; testing conducted prior to treatment
Charles 1960	Inadequate treatment dose
Charles 1962	Inadequate treatment dose
Chaudhuri 1950	Inadequate treatment dose
Chen 1999	Insufficient information on outcomes reported; treatment not administered to entire population
Cisse 2006	Individually randomized study
Cisse 2009	Treatment not administered to entire population; intermittent preventive treatment for children (IPTc) study
Ciuca 1937	Mixed curative and prophylactic dosing
Clark 1942	Testing conducted prior to treatment
Clarke 2008	Treatment not administered to entire population; intermittent preventive treatment for children (IPTc) study
Clyde 1958	Insufficient information on drug administration
Clyde 1961a	Insufficient information on outcomes reported
Clyde 1961b	Insufficient information on outcomes reported
Clyde 1962	Inadequate treatment dose
Coutinho 1962	Inadequate treatment dose
D'Anfreville 1930	Insufficient information on drug administration; insufficient information on outcomes reported (no outcome of interest reported)
Danquah 2009	Individually randomized study
Dapeng 1996	Insufficient information on drug administration; insufficient information on outcomes reported
de Mello 1938	Inadequate treatment dose
Decourt 1935	Inadequate treatment dose; individually randomized study
Decourt 1936	Inadequate treatment dose
Delmont 1981	Inadequate treatment dose; individually randomized study
Desowitz 1987	Insufficient information on drug administration
Diallo 1977	Inadequate treatment dose
Diallo 1983	Treatment not administered to entire population; intermittent preventive treatment in children (IPTc) study
Dicko 2008	Individually randomized study; testing conducted prior to treatment
Dicko 2011	Individually randomized study
Dixon 1950	Inadeqaute treatment dose
Doi 1989	Individually randomized study; testing conducted prior to treatment
Dola 1974	Inadequate treatment dose
Doucet 1947	Inadequate treatment dose
Downs 1946	Study participants did not remain in endemic area
Dupoux 1937	Insufficient information on outcomes reported
Dupoux 1939	Inadequate treatment dose
Edeson 1957	Inadequate treatment dose
Farinaud 1934	Insufficient information on drug administration
Farinaud 1950	Inadequate treatment dose
Gaud 1949	Inadequate treatment dose
Gilroy 1952	Inadequate treatment dose
Gomez Mendoza 1960	Insufficient information on outcomes reported
Gribben 1933	Inadequate treatment dose
Gruer 1962	Insufficient information on drug administration; insufficient information on outcomes of interest
Gunther 1951	Inadequate treatment dose
Gunther 1952	Mixed curative and prophylactic dosing
Gusmao 1970	Inadequate treatment dose; individually randomized study
Han 2006	Inadequate treatment dose
Harwin 1973	Individually randomized study
Henderson 1934	Mixed curative and prophylactic dosing
Ho 1965	Insufficient information on outcomes reported (no outcome of interest reported)
Houel 1954b	Treatment not administered to entire population (children only)
Huehne 1971	Post‐only outcomes reported
Janssens 1950	Inadequate treatment dose
Joncour 1956	Inadequate treatment dose
Kaneko 2010	Insufficient information on drug administration; insufficient information on outcomes reported.
Karimov 2008	Inadequate treatment dose
Kingsbury 1931	Inadequate treatment dose
Klopfer 1949	Inadequate treatment dose
Komp 1935	Testing conducted prior to treatment
Konate 2011	Individually randomized study
Kweku 2008	Individually randomized study
Kweku 2009	Insufficient information on outcomes reported; comparison of delivery strategies; treatment not administered to entire population (both arms included intermittent preventive treatment in children (IPTc))
Lacroix 1952	Inadequate treatment dose
Lahon 1960	Inadequate treatment dose
Laing 1970	Testing conducted prior to treatment
Laing 1984	Inadequate treatment dose
Lakshmanacharyulu 1968	Insufficient information on drug administration
Levenson 1943	Mixed curative and prophylactic dosing
Liljander 2010	Individually randomized study
Lui 1986	Mixed curative and prophylactic dosing
Lysenko 1960	Mixed curative and prophylactic dosing
MacCormack 1983	Inadequate treatment dose
Mackerras 1954	Inadequate treatment dose
Maiga 2009	Individually randomized study
Malaria_Army 1934	Inadequate treatment dose; insufficient information on outcomes reported
Mason 1973	Insufficient information on drug administration
Mason 1977	Insufficient information on drug administration
Mastbaum 1957a	Inadequate treatment dose
Mastbaum 1957b	Inadequate treatment dose
McGregor 1966	Individually randomized study; testing conducted prior to treatment
Melik‐Adamian 1938	Testing conducted prior to treatment
Mendez Galvan 1984	Insufficient information on drug administration; insufficient information on outcomes reported
Mercier 1953	Inadequate treatment dose
Merle 1955	Inadequate treatment dose; treatment not administered to entire population (eg intermittent preventive treatment for children (IPTc))
Mezincesco 1935	Inadequate treatment dose
Miller 1955	Inadequate treatment dose; individually randomized study; treatment not administered to entire population
Monteny 1960	Inadequate treatment dose
Mühlens 1913	Insufficient information on drug administration; insufficient information on outcomes of interest
Nakibuuka 2009	Individually randomized study; testing conducted prior to treatment
Nankabirwa 2010	Individually randomized study
Nave 1973	Insufficient information on outcomes reported
Norman 1952	Inadequate treatment dose; insufficient information on outcomes of interest
Ntab 2007	Individually randomized study; insufficient information on outcomes reported
Omer 1978	Inadequate treatment dose
Onori 1972	Inadequate treatment dose
Ossi 1967	Insufficient information on outcomes reported
Ouedraogo 2010	Individually randomized study
Parrot 1937	Inadequate treatment dose
Parrot 1943	Inadequate treatment dose
Parrot 1944	Inadequate treatment dose
Parrot 1946	Inadequate treatment dose
Peters 1962	Inadequate treatment dose
Phillips 1954	Inadequate treatment dose
Pikul 1934	Insufficient information on outcomes reported
Pribadi 1986	Inadequate treatment dose
Prokopenko 1945	Inadequate treatment dose
Rachou 1965	Inadequate treatment dose
Rafi 1951	Inadequate treatment dose
Ray 1948	Inadequate treatment dose
Robin 1946	Testing conducted prior to treatment
Rodríguez 1994	Testing conducted prior to treatment
Rohner 2010	Individually randomized study
Saarinen 1987	Mixed curative and prophylactic dosing
Salako 1990	Individually randomized study; testing conducted prior to treatment
Salihu 2000	Inadequate treatment dose
Santos 1993	Inadequate treatment dose
Schliessmann 1973	Insufficient information on outcomes reported
Schneider 1948a	Inadequate treatment dose
Schneider 1948b	Inadequate treatment dose
Schneider 1958	Inadequate treatment dose
Schneider 1962	Individually randomized study; treatment not administered to entire population (eg intermittent preventive treatment for children (IPTc))
Seckinger 1935	Inadequate treatment dose
Sehgal 1968	Insufficient information on drug administration
Sergent 1913	Inadequate treatment dose; insufficient information on outcomes reported
Sesay 2011	Individually randomized study
Shanks 1992	Inadequate treatment dose; individually randomized study; testing conducted prior to treatment
Shanks 1993	Individually randomized study; study participants did not remain in endemic area
Shanks 1995a	Inadequate treatment dose; study participants did not remain in endemic area
Shanks 1995b	Study participants did not remain in endemic area
Sheinker 1945	Testing conducted prior to treatment
Singh 1968	Insufficient information on outcomes reported
Snowden 2006	Insufficient information on drug administration; insufficient information on outcomes reported
Sokhna 2008	Individually randomized study
Sorel 1913	Insufficient information on drug administration
Srivastava 1950	Inadequate treatment dose
Strangeways‐Dixon 1950	Inadequate treatment dose
Strickland 1986	Testing conducted prior to treatment
Swellengrebel 1931	Inadequate treatment dose
Tagbor 2011	Treatment not administered to entire population; intermittent preventive treatment for children (IPTc) study
Tine 2011	Treatment not administered to entire population; intermittent preventive treatment for children (IPTc) study
Turner 1977	Insufficient information on outcomes reported
Usenbaev 2006	Insufficient information on drug administration
Usenbaev 2008	Insufficient information on drug administration
Van Dijk 1958	Inadequate treatment dose
Van Goor 1950	Inadequate treatment dose
Verhoef 2002	Individually randomized study
Villegas 2010	Testing conducted prior to treatment
Wallace 1936	Mixed curative and prophylactic dosing
Wallace 1954	Insufficient information on drug administration
Watkins 1987	Individually randomized; mixed curative and prophylactic dosing
White 1934	Inadequate treatment dose
White 1937	Mixed curative and prophylactic dosing
Winter 1934	Insufficient information on outcomes reported
Wone 1967	Inadequate treatment dose
Yip 1998	Insufficient information on outcomes reported